Meta-Analysis of Phase I Dose-Finding Early Clinical Trials

Meta-analysis approaches for Phase I dose finding early phases clinical trials in order to better suit requirements in terms of maximum tolerated dose (MTD) and maximal dose regimen (MDR). This package has currently three different approaches: (a) an approach proposed by Zohar et al, 2011, (denoted as ZKO), (b) the Variance Weighted pooling analysis (called VarWT) and (c) the Random Effects Model Based (REMB) algorithm, where user can input his/her own model based approach or use the existing random effect logistic regression model (named as glimem) through the 'dfmeta' package.

CRAN Version


The dfmeta package includes meta-analysis approaches for Phase I dose finding early phases clinical trials in order to better suit requirements in terms of the maximum tolerated dose (MTD) and the maximal dose regimem (MDR).


Establish Version

The 1st version of the package dfmeta will be available on CRAN very soon and it will be loaded via


Development Version

To install the dfmeta package from GitHub, first make sure that you can install the necessary depended packages such as stats4, lme4, plyr etc. Once the depended packages are successfully installed, you can install dfmeta from GitHub using the devtools package by executing the following in R:

if (!require(devtools)){

If installation fails, please let us know by filing an issue.

Details on formula syntax, families and link functions, as well as prior distributions can be found on the help page of the dfmeta function:



What is the best way to ask a question or propose a new feature?

You can either open an issue on github or write me an email to ([email protected]).


Reference manual

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1.0.0 by Artemis Toumazi, 2 years ago

Report a bug at

Browse source code at

Authors: Artemis Toumazi <[email protected]> , Sarah Zohar <[email protected]> , Anand N. Vidyashankar <[email protected]> , Jie Xu <[email protected]> and Moreno Ursino <[email protected]>

Documentation:   PDF Manual  

Task views: Meta-Analysis

GPL (>= 3) | file LICENSE license

Imports ggplot2, methods, graphics, grDevices, stats, utils

Depends on lme4, stats4, plyr, data.table

System requirements: C++11

See at CRAN