Meta-analysis approaches for Phase I dose finding early phases clinical trials in order to better suit requirements in terms of maximum tolerated dose (MTD) and maximal dose regimen (MDR). This package has currently three different approaches: (a) an approach proposed by Zohar et al, 2011,
The dfmeta package includes meta-analysis approaches for Phase I dose finding early phases clinical trials in order to better suit requirements in terms of the maximum tolerated dose (MTD) and the maximal dose regimem (MDR).
The 1st version of the package dfmeta will be available on CRAN very soon and it will be loaded via
To install the dfmeta package from GitHub, first make sure that you can install the necessary depended packages such as stats4, lme4, plyr etc. Once the depended packages are successfully installed, you can install dfmeta from GitHub using the devtools package by executing the following in R:
If installation fails, please let us know by filing an issue.
Details on formula syntax, families and link functions, as well as prior distributions can be found on the help page of the dfmeta function: