Vaccine Efficacy Over Time

Implements methods for inference on potential waning of vaccine efficacy and for estimation of vaccine efficacy at a user-specified time after vaccination based on data from a randomized, double-blind, placebo-controlled vaccine trial in which participants may be unblinded and placebo subjects may be crossed over to the study vaccine. The methods also allow adjustment for possible confounding via inverse probability weighting through specification of models for the trial entry process, unblinding mechanisms, and the probability an unblinded placebo participant accepts study vaccine: Tsiatis, A. A. and Davidian, M. (2021) .


Reference manual

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1.1 by Shannon Holloway, 5 days ago

Browse source code at

Authors: Marie Davidian [aut] , A.A. Tsiatis [aut] , Shannon Holloway [aut, cre]

Documentation:   PDF Manual  

GPL-2 license

Depends on survival, stats, graphics, ggplot2

See at CRAN