Robust Estimation of Conditional 2D Reference Regions

Provides tools for constructing conditional two-dimensional reference regions in continuous data, particularly suited for clinical, biological, or epidemiological studies requiring robust multivariate assessment. The implemented methodology combines directional quantiles with median‑based partial correlation models to produce reliable and interpretable reference regions even in the presence of outliers. Key features include robust conditional modeling for two responses conditioned on covariates, directional quantile regions, cross‑validation of coverage, visualization tools, and flexible formula‑based inputs.


Reference manual

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install.packages("TwoDiRef")

0.1.0 by Oscar Lado-Baleato, 6 months ago


Browse source code at https://github.com/cran/TwoDiRef


Authors: Oscar Lado-Baleato [aut, cre] , Sara Rodriguez-Pastoriza [aut] , Javier Roca-Pardinas [aut]


Documentation:   PDF Manual  


GPL-3 license


Imports qgam, mgcv, sp, ggplot2, scales, shiny

Suggests refreg


See at CRAN