Causal Analysis of Observational Time-to-Event Data

Implements target trial emulation methods to apply randomized clinical trial design and analysis in an observational setting. Using marginal structural models, it can estimate intention-to-treat and per-protocol effects in emulated trials using electronic health records. A description and application of the method can be found in Danaei et al (2013) .

TrialEmulation

This package implements algorithms to conduct a sequence of target trials analysis.

Installation

The package is available on CRAN:

install.packages('TrialEmulation')

To install the latest development version from github:

remotes::install_github("Causal-LDA/TrialEmulation")

Getting Started

Please see our Getting Started vignette for information on how to work with this package.

A manuscript is in preparation to fully describe the methodology.