Repertoire Graphical Visualization

Visualization platform for T cell receptor repertoire analysis output results. It includes comparison of sequence frequency among samples, network of similar sequences and convergent recombination source between species. Currently repertoire analysis is in early stage of development and requires new approaches for repertoire data examination and assessment as we intend to develop. No publication is available yet (will be available in the near future), Efroni (2021) .

RepertoiR

Installation

You can install the development version of RepertoiR from version from GitHub with:

# install.packages("devtools")
devtools::install_github("systemsbiomed/RepertoiR")

Quick demo

Creating network graph of TCR repertoire’s clonotypes:

library(RepertoiR)

aa <- c(
  "G", "A", "V", "L", "I", "P", "F", "Y", "W", "S",
  "T", "N", "Q", "C", "M", "D", "E", "H", "K", "R"
)
data <- matrix(rexp(1 / 2, n = 1000), ncol = 4)
cons <- sample(aa, 10)
aavec <- c()

while (length(aavec) < nrow(data)) {
  aaseq <- cons
  index <- sample(length(aaseq), sample(length(aaseq) / 3, 1))
  aaseq[index] <- sample(aa, length(index), replace = TRUE)
  aaseq <- paste0(aaseq, collapse = "")
  aavec <- unique(append(aavec, aaseq))
}

rownames(data) <- aavec
colnames(data) <- LETTERS[1:ncol(data)]