Prioritizing Cancer Drugs for Interested Cancer

Prioritize candidate cancer drugs for drug repositioning based on the random walk with restart algorithm in a drug-drug functional similarity network. 1) We firstly constructed a drug-drug functional similarity network by integrating pathway activity and drug activity derived from the NCI-60 cancer cell lines. 2) Secondly, we calculated drug repurposing score according to a set of approved therapeutic drugs of interested cancer based on the random walk with restart algorithm in the drug-drug functional similarity network. 3) Finally, the permutation test was used to calculate the statistical significance level for the drug repurposing score.


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0.1.0 by Junwei Han, 3 years ago

Browse source code at

Authors: Junwei Han [ctb, cre] , Jieyi Di [aut] , Baotong Zheng [aut]

Documentation:   PDF Manual  

GPL (>= 2) license

Imports igraph, dplyr, ROCR, visNetwork

Suggests knitr, rmarkdown

See at CRAN