Design and Monitoring of Survival Trials Accounting for Complex Situations

Calculates various functions needed for design and monitoring survival trials accounting for complex situations such as delayed treatment effect, treatment crossover, non-uniform accrual, and different censoring distributions between groups. The event time distribution is assumed to be piecewise exponential (PWE) distribution and the entry time is assumed to be piecewise uniform distribution. As compared with Version 1.2.1, two more types of hybrid crossover are added. A bug is corrected in the function "pwecx" that calculates the crossover-adjusted survival, distribution, density, hazard and cumulative hazard functions. Also, to generate the crossover-adjusted event time random variable, a more efficient algorithm is used and the output includes crossover indicators.


News

Reference manual

It appears you don't have a PDF plugin for this browser. You can click here to download the reference manual.

install.packages("PWEALL")

1.3.0 by Xiaodong Luo, 3 years ago


Browse source code at https://github.com/cran/PWEALL


Authors: Xiaodong Luo [aut, cre] , Xuezhou Mao [ctb] , Xun Chen [ctb] , Hui Quan [ctb] , Sanofi [cph]


Documentation:   PDF Manual  


GPL (>= 2) license


Imports survival, stats


Imported by NBDesign, goldilocks.


See at CRAN