Design and Monitoring of Clinical Trials with Negative Binomial Endpoint

Calculate various functions needed for design and monitoring clinical trials with negative binomial endpoint with variable follow-up. This version has a few changes compared to the previous version 1.0.0, including (1) correct a typo in Type 1 censoring, mtbnull=bnull and (2) restructure the code to account for shape parameter equal to zero, i.e. Poisson scenario.


Reference manual

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2.0.0 by Xiaodong Luo, a year ago

Browse source code at

Authors: Xiaodong Luo [aut, cre] , Sanofi [cph]

Documentation:   PDF Manual  

GPL (>= 2) license

Imports stats, PWEALL, MASS

See at CRAN