High-Dimensional Mediation Analysis

Allows to estimate and test high-dimensional mediation effects based on advanced mediator screening and penalized regression techniques. Methods used in the package refer to Haixiang Zhang, Yinan Zheng, Zhou Zhang, Tao Gao, Brian Joyce, Grace Yoon, Wei Zhang, Joel Schwartz, Allan Just, Elena Colicino, Pantel Vokonas, Lihui Zhao, Jinchi Lv, Andrea Baccarelli, Lifang Hou, Lei Liu (2016) .

GitHub release

HIMA is an R package for estimating and testing high-dimensional mediation effects in genomic/epigenomic studies.


HIMA is now available in R CRAN repository

## Install REMP


Zhang H, Zheng Y, Zhang Z, Gao T, Joyce B, Yoon G, Zhang W, Schwartz J, Just A, Colicino E, Vokonas P, Zhao L, Lv J, Baccarelli A, Hou L, Liu L. Estimating and Testing High-dimensional Mediation Effects in Epigenetic Studies. Bioinformatics. 2016. DOI: http://dx.doi.org/10.1093/bioinformatics/btw351. PubMed PMID: 27357171.

Contact package maintainer:

Yinan Zheng

Email: [email protected]


HIMA 1.0.0 (2016-07-09)

  • Initial package submission to GitHub

REMP 1.0.2 (2016-12-13)

  • Improvement: More powerful model fit when outcome variable is binary.
  • New: Generalized linear regression is now allowed in screening step.

REMP 1.0.3 (2017-03-30)

  • Improvement: Added error handler when no mediators were selected from penalized model.
  • Improvement: More transparent information returned during model fitting (when verbose = TRUE).

REMP 1.0.4 (2017-04-08)

  • Improvement: Benjamini-Hochberg FDR adjustment is available.

REMP 1.0.5 (2017-11-05)

  • Improvement: Two different sets of covariates are allowed for step 1 and step 2 separately.

REMP 1.0.7 (2018-03-06)

  • Allow low-dimensional mediator selections.

Reference manual

It appears you don't have a PDF plugin for this browser. You can click here to download the reference manual.


1.1.0 by Yinan Zheng, 8 months ago


Report a bug at https://github.com/YinanZheng/HIMA/issues/

Browse source code at https://github.com/cran/HIMA

Authors: Yinan Zheng [aut, cre] , Haixiang Zhang [aut] , Lifang Hou [aut] , Lei Liu [aut, cph]

Documentation:   PDF Manual  

GPL-3 license

Imports utils, stats, MASS, survival, HDMT, iterators, parallel, foreach, doParallel

Depends on ncvreg, glmnet

See at CRAN