Family Age-at-Onset Data Simulation and Penetrance Estimation

Simulates age-at-onset traits associated with a segregating major gene in family data obtained from population-based, clinic-based, or multi-stage designs. Appropriate ascertainment correction is utilized to estimate age-dependent penetrance functions either parametrically from the fitted model or nonparametrically from the data. The Expectation and Maximization algorithm can infer missing genotypes and carrier probabilities estimated from family's genotype and phenotype information or from a fitted model. Plot functions include pedigrees of simulated families and predicted penetrance curves based on specified parameter values.


Reference manual

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1.3 by Yun-Hee Choi, 2 years ago

Browse source code at

Authors: Yun-Hee Choi , Karen Kopciuk , Wenqing He , Laurent Briollais

Documentation:   PDF Manual  

Task views: Survival Analysis, Missing Data

GPL (>= 2.0) license

Depends on base, MASS, truncnorm, survival, kinship2

See at CRAN