Drug Repurposing in Cancer via a Subpathway Crosstalk Network

A systematic biology tool was developed to repurpose drugs via a subpathway crosstalk network. The operation modes include 1) evaluating the eigenvector centrality (centrality score) of subpathways and identifying dysregulated subpathways in the subpathway-subpathway network, 2) evaluating the activity of subpathways by GSEA and weighting them with corresponding centrality score, 3) identifying optimal drugs for specific disease through constructing disease-drug reverse association based on the weighted activity of subpathways. There are also several functions used to visualize the results.


Reference manual

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0.1.0 by Junwei Han, a month ago

Browse source code at https://github.com/cran/DRviaSPCN

Authors: Junwei Han [aut, cre, cph] , Jiashuo Wu [aut]

Documentation:   PDF Manual  

GPL (>= 2) license

Imports ChemmineR, GSVA, clusterProfiler, graphics, igraph, pheatmap, rvest, xml2, stats

Suggests rmarkdown, knitr

See at CRAN