Statistical Functions for the Design of Studies with Composite Endpoints

It has been designed to calculate the required sample size in randomized clinical trials with composite endpoints. This package also includes functions to calculate the probability of observing the composite endpoint and the expected effect on the composite endpoint, among others. The methods implemented can be found in Bofill & Gómez (2019) and Gómez & Lagakos (2013) .


Reference manual

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1.9 by Marta Bofill Roig, a day ago

Browse source code at

Authors: Marta Bofill Roig [aut, cre] , Jordi Cortes Martinez [aut] , Guadalupe Gomez Melis [ctb]

Documentation:   PDF Manual  

GPL-3 license

Imports stats, copula, ggplot2, rootSolve, numDeriv

See at CRAN