Biomarker Prognostic Enrichment Tool for Time-to-Event Trial

Prognostic Enrichment is a strategy of enriching a clinical trial for testing an intervention intended to prevent or delay an unwanted clinical event. A prognostically enriched trial enrolls only patients who are more likely to experience the unwanted clinical event than the broader patient population (R. Temple (2010) ). By testing the intervention in an enriched study population, the trial may be adequately powered with a smaller sample size, which can have both practical and ethical advantages. This package provides tools to evaluate biomarkers for prognostic enrichment of clinical trials with survival/time-to-event outcomes.


Reference manual

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0.1.0 by Si Cheng, a year ago

Browse source code at

Authors: Si Cheng [cre, aut] , Kathleen F. Kerr [ctb]

Documentation:   PDF Manual  

GPL (>= 2) license

Imports survival, ggplot2, gridExtra

See at CRAN