Metadata Processing for the German Modification of the ICD-10 Coding System

Provides convenient access to the German modification of the International Classification of Diagnoses, 10th revision (ICD-10-GM). It provides functionality to aid in the identification, specification and historisation of ICD-10 codes. Its intended use is the analysis of routinely collected data in the context of epidemiology, medical research and health services research. The underlying metadata are released by the German Institute for Medical Documentation and Information < https://www.dimdi.de>, and are redistributed in accordance with their license.

The BETS Model for Early Epidemic Data

Implements likelihood inference for early epidemic analysis. BETS is short for the four key epidemiological events being modeled: Begin of exposure, End of exposure, time of Transmission, and time of Symptom onset. The package contains a dataset of the trajectory of confirmed cases during the coronavirus disease (COVID-19) early outbreak. More detail of the statistical methods can be found in Zhao et al. (2020) .

Stratified Analysis of 2x2 Contingency Tables

Offers a comprehensive approach for analysing stratified 2x2 contingency tables. It facilitates the calculation of odds ratios, 95% confidence intervals, and conducts chi-squared, Cochran-Mantel-Haenszel, Mantel-Haenszel, and Breslow-Day-Tarone tests. The package is particularly useful in fields like epidemiology and social sciences where stratified analysis is essential. The package also provides interpretative insights into the results, aiding in the understanding of statistical outcomes.

Bayesian Variable Selection for SNP Data using Normal-Gamma

Posterior distribution of case-control fine-mapping. Specifically, Bayesian variable selection for single-nucleotide polymorphism (SNP) data using the normal-gamma prior. Alenazi A.A., Cox A., Juarez M,. Lin W-Y. and Walters, K. (2019) Bayesian variable selection using partially observed categorical prior information in fine-mapping association studies, Genetic Epidemiology. .

Construct Polygons Summarising the Location and Variability of Point Sets

Various applications in invasive species biology, conservation biology, epidemiology and elsewhere involve sampling of sets of 2D points from a posterior distribution. The number of such point sets may be large, say 1000 or 10000. This package facilitates visualisation of such output by constructing seven nested polygons representing the location and variability of the point sets. This can be used, for example, to visualise the range boundary of a species, and uncertainty in the location of that boundary.

Approximate Optimal Experimental Designs Using Generalised Linear Mixed Models

Optimal design analysis algorithms for any study design that can be represented or modelled as a generalised linear mixed model including cluster randomised trials, cohort studies, spatial and temporal epidemiological studies, and split-plot designs. See < https://github.com/samuel-watson/glmmrBase/blob/master/README.md> for a detailed manual on model specification. A detailed discussion of the methods in this package can be found in Watson, Hemming, and Girling (2023) .

'Mica' Data Web Portal Client

'Mica' is a server application used to create data web portals for large-scale epidemiological studies or multiple-study consortia. 'Mica' helps studies to provide scientifically robust data visibility and web presence without significant information technology effort. 'Mica' provides a structured description of consortia, studies, annotated and searchable data dictionaries, and data access request management. This 'Mica' client allows to perform data extraction for reporting purposes.

Bayesian Joint Latent Class and Regression Models

For fitting Bayesian joint latent class and regression models using Gibbs sampling. See the documentation for the model. The technical details of the model implemented here are described in Elliott, Michael R., Zhao, Zhangchen, Mukherjee, Bhramar, Kanaya, Alka, Needham, Belinda L., "Methods to account for uncertainty in latent class assignments when using latent classes as predictors in regression models, with application to acculturation strategy measures" (2020) In press at Epidemiology .

Multi-Block Partial Least Squares Discriminant Analysis

Several functions are provided to implement a MBPLSDA : components search, optimal model components number search, optimal model validity test by permutation tests, observed values evaluation of optimal model parameters and predicted categories, bootstrap values evaluation of optimal model parameters and predicted cross-validated categories. The use of this package is described in Brandolini-Bunlon et al (2019. Multi-block PLS discriminant analysis for the joint analysis of metabolomic and epidemiological data. Metabolomics, 15(10):134).

A Flexible Syntax for Population Dynamic Modelling

Population dynamic models underpin a range of analyses and applications in ecology and epidemiology. The various approaches for analysing population dynamics models (MPMs, IPMs, ODEs, POMPs, PVA) each require the model to be defined in a different way. This makes it difficult to combine different modelling approaches and data types to solve a given problem. 'pop' aims to provide a flexible and easy to use common interface for constructing population dynamic models and enabling to them to be fitted and analysed in lots of different ways.