Easy Spatial Microsimulation (Raking) in R

Functions for performing spatial microsimulation ('raking') in R.

Alluvial Diagrams

Creating alluvial diagrams (also known as parallel sets plots) for multivariate and time series-like data.

Simulate Data from a (Time-Dependent) Causal DAG

Simulate complex data from a given directed acyclic graph and information about each individual node. Root nodes are simply sampled from the specified distribution. Child Nodes are simulated according to one of many implemented regressions, such as logistic regression, linear regression, poisson regression or any other function. Also includes a comprehensive framework for discrete-time simulation, discrete-event simulation, and networks-based simulation which can generate even more complex longitudinal and dependent data. For more details, see Robin Denz, Nina Timmesfeld (2025) .

Meta-Package for Thematic Mapping with 'tmap'

Attaches a set of packages commonly used for spatial plotting with 'tmap'. It includes 'tmap' and its extensions ('tmap.glyphs', 'tmap.networks', 'tmap.cartogram', 'tmap.mapgl'), as well as supporting spatial data packages ('sf', 'stars', 'terra') and 'cols4all' for exploring color palettes. The collection is designed for thematic mapping workflows and does not include the full set of packages from the R-spatial ecosystem.

Bayesian Calibration of Complex Computer Codes

Performs Bayesian calibration of computer models as per Kennedy and O'Hagan 2001. The package includes routines to find the hyperparameters and parameters; see the help page for stage1() for a worked example using the toy dataset. A tutorial is provided in the calex.Rnw vignette; and a suite of especially simple one dimensional examples appears in inst/doc/one.dim/.

Sparse Arrays and Multivariate Polynomials

Sparse arrays interpreted as multivariate polynomials. Uses 'disordR' discipline (Hankin, 2022, ). To cite the package in publications please use Hankin (2022) .

Optimal Exact Tests for Multiple Binary Endpoints

Calculates exact hypothesis tests to compare a treatment and a reference group with respect to multiple binary endpoints. The tested null hypothesis is an identical multidimensional distribution of successes and failures in both groups. The alternative hypothesis is a larger success proportion in the treatment group in at least one endpoint. The tests are based on the multivariate permutation distribution of subjects between the two groups. For this permutation distribution, rejection regions are calculated that satisfy one of different possible optimization criteria. In particular, regions with maximal exhaustion of the nominal significance level, maximal power under a specified alternative or maximal number of elements can be found. Optimization is achieved by a branch-and-bound algorithm. By application of the closed testing principle, the global hypothesis tests are extended to multiple testing procedures.

Optimum Contribution Selection and Population Genetics

A framework for the optimization of breeding programs via optimum contribution selection and mate allocation. An easy to use set of function for computation of optimum contributions of selection candidates, and of the population genetic parameters to be optimized. These parameters can be estimated using pedigree or genotype information, and include kinships, kinships at native haplotype segments, and breed composition of crossbred individuals. They are suitable for managing genetic diversity, removing introgressed genetic material, and accelerating genetic gain. Additionally, functions are provided for computing genetic contributions from ancestors, inbreeding coefficients, the native effective size, the native genome equivalent, pedigree completeness, and for preparing and plotting pedigrees. The methods are described in:\n Wellmann, R., and Pfeiffer, I. (2009) .\n Wellmann, R., and Bennewitz, J. (2011) .\n Wellmann, R., Hartwig, S., Bennewitz, J. (2012) .\n de Cara, M. A. R., Villanueva, B., Toro, M. A., Fernandez, J. (2013) .\n Wellmann, R., Bennewitz, J., Meuwissen, T.H.E. (2014) .\n Wellmann, R. (2019) .

Open GenBank Files

Opens complete record(s) with .gb extension from the NCBI/GenBank Nucleotide database and returns a list containing shaped record(s). These kind of files contains detailed records of DNA samples (locus, organism, type of sequence, source of the sequence...). An example of record can be found at < https://www.ncbi.nlm.nih.gov/nuccore/HE799070>.

Calculate the Care Density or Fragmented Care Density Given a Patient-Sharing Network

Given a patient-sharing network, calculate either the classic care density as proposed by Pollack et al. (2013) or the fragmented care density as proposed by Engels et al. (2024) . By utilizing the 'igraph' and 'data.table' packages, the provided functions scale well for very large graphs.