Interact with Online Differential Diagnosis-Generating Tools

Freely available online differential-diagnosis generating tools are changing clinical medicine and biomedical research. With webddx, useRs can generate differential diagnosis lists given a set of symptoms. The web tools would likely be directly used in clinical practice, but programmatic interaction and data manipulation can sharply increase efficiency and reproducibility of research in clinical informatics. Relevant visualizations can also be created with webddx.

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License: GPL v3 CRAN version CRAN Downloads


webddx is an R package allowing for programmatic interaction with web-based differential diagnosis-generating tools. It provides an API client for popular tools (e.g. OMIM) with complementary functionality (e.g. visualization) to serve as an effective tool in clinical informatics research.


To install webddx, run the following R code:

# install from CRAN
# install development version from GitHub
# install development version with vignettes/tutorials
devtools::install_github("rrrlw/webddx", build_vignettes = TRUE)

Sample code

# load webddx
# query FindZebra for rare diseases involving muscle pain and fatigue
query_fz(query = c("muscle pain", "fatigue"))

See the documentation of query_fz for information on customizing FindZebra queries using additional parameters.


Currently, webddx implements an API client for FindZebra. Development is focused on adding an API client for OMIM.


To contribute to webddx, you can create issues for any bugs/suggestions on the issues page. You can also fork the webddx repository and create pull requests to implement features.


Reference manual

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0.1.0 by Raoul Wadhwa, a year ago

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Browse source code at

Authors: Raoul Wadhwa [aut, cre] , Marvin Natowicz [aut] , Deborah Park [ctb]

Documentation:   PDF Manual  

GPL-3 license

Imports jsonlite

Suggests covr, testthat

See at CRAN