Contains a suite of functions for survival analysis in health economics. These can be used to run survival models under a frequentist (based on maximum likelihood) or a Bayesian approach (both based on Integrated Nested Laplace Approximation or Hamiltonian Monte Carlo). The user can specify a set of parametric models using a common notation and select the preferred mode of inference. The results can also be post-processed to produce probabilistic sensitivity analysis and can be used to export the output to an Excel file (e.g. for a Markov model, as often done by modellers and practitioners).
Contains a suite of functions to systematise the workflow involving survival analysis in health economic evaluation. survHE can fit a large range of survival models using both a frequentist approach (by calling the R package flexsurv) and a Bayesian perspective. For a selected range of models, both Integrated Nested Laplace Integration (via the R package INLA) and Hamiltonian Monte Carlo (via the R package rstan) are possible. HMC models are pre-compiled so that they can run in a very efficient and fast way. In addition to model fitting, survHE provides a set of specialised functions, for example to perform Probabilistic Sensitivity Analysis, export the results of the modelling to a spreadsheet, plotting survival curves and uncertainty around the mean estimates.
There are two ways of installing
survHE. A "stable" version is packaged and binary files are available for Windows and as source. To install the stable version on a Windows machine, run the following commands
Note that you need to specify a vector of repositories - the first one hosts
survHE, while the second one should be an official CRAN mirror. You can select whichever one you like, but a CRAN mirror must be provided, so that
install.packages() can also install the "dependencies" (e.g. other packages that are required for
survHE to work). The third one is used to install the package
INLA, which is used to do one version of the Bayesian analysis. This process can be quite lengthy, if you miss many of the relevant packages.
To install from source (e.g. on a Linux machine), run
The second way involves using the "development" version of
survHE - this will usually be updated more frequently and may be continuously tested. On Windows machines, you need to install a few dependencies, including Rtools first, e.g. by running
pkgs <- c("flexsurv","Rcpp","rms","xlsx","rstan","INLA","Rtools","devtools")repos <- c("", "")install.packages(pkgs,repos=repos,dependencies = "Depends")
before installing the package using
Under Linux or MacOS, it is sufficient to install the package via