Design and Simulation of seamless Phase II-III Clinical Trials

Provides methods for generating, exploring and executing seamless Phase II-III designs of Lai, Lavori and Shih using generalized likelihood ratio statistics. Includes pdf and source files that describe the entire R implementation with the relevant mathematical details.


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Reference manual

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install.packages("sp23design")

0.9 by Balasubramanian Narasimhan, 5 years ago


Browse source code at https://github.com/cran/sp23design


Authors: Balasubramanian Narasimhan [aut, cre] , Mei-Chiung Shih [aut] , Pei He [aut]


Documentation:   PDF Manual  


Task views: Design of Experiments (DoE) & Analysis of Experimental Data


LGPL-3 license


Depends on mvtnorm, survival

Suggests RUnit


See at CRAN