Design and Simulation of seamless Phase II-III Clinical Trials

Provides methods for generating, exploring and executing seamless Phase II-III designs of Lai, Lavori and Shih using generalized likelihood ratio statistics. Includes pdf and source files that describe the entire R implementation with the relevant mathematical details.


Reference manual

It appears you don't have a PDF plugin for this browser. You can click here to download the reference manual.


0.9 by Balasubramanian Narasimhan, 7 years ago

Browse source code at

Authors: Balasubramanian Narasimhan [aut, cre] , Mei-Chiung Shih [aut] , Pei He [aut]

Documentation:   PDF Manual  

Task views: Design of Experiments (DoE) & Analysis of Experimental Data

LGPL-3 license

Depends on mvtnorm, survival

Suggests RUnit

See at CRAN