Average Bioequivalence with Expanding Limits (ABEL)

Performs comparative bioavailability calculations for the EMA's Average Bioequivalence with Expanding Limits (ABEL). Implemented are 'Method A' and 'Method B', detection of outliers. If the design allows, assessment of the empiric Type I Error and iteratively adjusting alpha to control the consumer risk. Average Bioequivalence (ABE) - optionally with tighter (EMA: NTIDs) or wider limits (GCC: Cmax) - is implemented as well.


Reference manual

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1.0.12 by Helmut Schütz, 24 days ago


Report a bug at https://github.com/Helmut01/replicateBE/issues

Browse source code at https://github.com/cran/replicateBE

Authors: Helmut Schütz [aut, cre] , Michael Tomashevskiy [ctb] , Detlew Labes [ctb]

Documentation:   PDF Manual  

GPL (>= 3) license

Imports readxl, PowerTOST, lmerTest, nlme, pbkrtest, graphics, grDevices

Suggests knitr, rmarkdown, testthat, devtools

See at CRAN