Average Bioequivalence with Expanding Limits (ABEL)

Performs comparative bioavailability calculations for the EMA's Average Bioequivalence with Expanding Limits (ABEL). Implemented are 'Method A' and 'Method B', detection of outliers. If the design allows, assessment of the empiric Type I Error and iteratively adjusting alpha to control the consumer risk. Average Bioequivalence (ABE) - optionally with tighter (EMA: NTIDs) or wider limits (GCC: Cmax) - is implemented as well.


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install.packages("replicateBE")

1.0.12 by Helmut Schütz, 24 days ago


https://github.com/Helmut01/replicateBE


Report a bug at https://github.com/Helmut01/replicateBE/issues


Browse source code at https://github.com/cran/replicateBE


Authors: Helmut Schütz [aut, cre] , Michael Tomashevskiy [ctb] , Detlew Labes [ctb]


Documentation:   PDF Manual  


GPL (>= 3) license


Imports readxl, PowerTOST, lmerTest, nlme, pbkrtest, graphics, grDevices

Suggests knitr, rmarkdown, testthat, devtools


See at CRAN