Flexible Identification of Phenotype-Specific Subpathways

A network-based systems biology tool for flexible identification of phenotype-specific subpathways in the cancer gene expression data with multiple categories (such as multiple subtype or developmental stages of cancer). Subtype Set Enrichment Analysis (SubSEA) and Dynamic Changed Subpathway Analysis (DCSA) are developed to flexible identify subtype specific and dynamic changed subpathways respectively. The operation modes include extraction of subpathways from biological pathways, inference of subpathway activities in the context of gene expression data, identification of subtype specific subpathways with SubSEA, identification of dynamic changed subpathways associated with the cancer developmental stage with DCSA, and visualization of the activities of resulting subpathways by using box plots and heat maps. Its capabilities render the tool could find the specific abnormal subpathways in the cancer dataset with multi-phenotype samples.


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install.packages("psSubpathway")

0.1.1 by Junwei Han, 2 months ago


Browse source code at https://github.com/cran/psSubpathway


Authors: Xudong Han , Junwei Han , Qingfei Kong


Documentation:   PDF Manual  


GPL (>= 2) license


Imports GSVA, igraph, mpmi, pheatmap

Suggests knitr, rmarkdown


See at CRAN