Normalised Prediction Distribution Errors for Nonlinear Mixed-Effect Models

Provides routines to compute normalised prediction distribution errors, a metric designed to evaluate non-linear mixed effect models such as those used in pharmacokinetics and pharmacodynamics. Documentation about 'npde' is provided by a comprehensive user guide on the github repository (<>), and references concerning the methods include the papers by Brendel et al. (2006, ; 2010, ), Comets et al. (2008, ; 2010, <>), and Nguyen et al. (2012, ). See 'citation("npde")' for details.


Reference manual

It appears you don't have a PDF plugin for this browser. You can click here to download the reference manual.


3.1 by Emmanuelle Comets, 7 months ago

Browse source code at

Authors: Emmanuelle Comets [aut, cre] , Karl Brendel [ctb] , Thi Huyen Tram Nguyen [ctb] , Romain Leroux [ctb] , France Mentre [ctb]

Documentation:   PDF Manual  

Task views:

GPL (>= 2) license

Imports methods, scales, mclust, rlang

Depends on gridExtra, ggplot2, grid

See at CRAN