latent effect adjustment after primary projection

These functions take a gene expression value matrix, a primary covariate vector, an additional known covariates matrix. A two stage analysis is applied to counter the effects of latent variables on the rankings of hypotheses. The estimation and adjustment of latent effects are proposed by Sun, Zhang and Owen (2011). "leapp" is developed in the context of microarray experiments, but may be used as a general tool for high throughput data sets where dependence may be involved.


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install.packages("leapp")

1.2 by Yunting Sun, 5 years ago


Browse source code at https://github.com/cran/leapp


Authors: Yunting Sun <[email protected]> , Nancy R.Zhang <[email protected]> , Art B.Owen <[email protected]>


Documentation:   PDF Manual  


GPL (>= 2) license


Depends on sva, MASS, corpcor


Imported by cate.


See at CRAN