Group Response Adaptive Randomization for Clinical Trials
Implements group response-adaptive randomization procedures, which include standard (non-group) response-adaptive randomization methods as special cases. The package also handles delayed and missing responses, which broadens its use in real-world trials. It offers functions for simulating a variety of response-adaptive randomization procedures, to help guide the choice of design for a clinical trial, including the doubly adaptive biased coin design and the multi-arm efficient randomized adaptive design (ERADE), k-arm optimal target allocations, group sequential monitoring, and a function that computes allocation probabilities for an ongoing trial. For details of the methods and algorithms, see the following references:
Wei, L. J. (1979) ;
Wei, L. J. and Durham, S. (1978) ;
Durham, S. D., Flournoy, N. and Li, W. (1998) ;
Ivanova, A., Rosenberger, W. F., Durham, S. D. and Flournoy, N. (2000) < https://www.jstor.org/stable/25053121>;
Bai, Z. D., Hu, F. and Shen, L. (2002) ;
Ivanova, A. (2003) ;
Hu, F. and Zhang, L. X. (2004) ;
Hu, F. and Rosenberger, W. F. (2006, ISBN:978-0-471-65396-7);
Zhang, L. X., Chan, W. S., Cheung, S. H. and Hu, F. (2007) < https://www.jstor.org/stable/26432528>;
Zhang, L. and Rosenberger, W. F. (2006) ;
Hu, F., Zhang, L. X., Cheung, S. H. and Chan, W. S. (2008) ;
Tymofyeyev, Y., Rosenberger, W. F. and Hu, F. (2007) ;
Hu, F., Zhang, L. X. and He, X. (2009) ;
Zhu, H. and Hu, F. (2010) ;
Zhai, G., Li, Y., Zhang, L. and Hu, F. (2024) ;
Alkhnefr, N., Hu, F. and Zhai, G. (2025) .