Design and Analysis of a 2x2 Factorial Trial

Used for the design and analysis of a 2x2 factorial trial for a time-to-event endpoint. It performs power calculations and significance testing as well as providing estimates of the relevant hazard ratios and the corresponding 95% confidence intervals. Important reference papers include Slud EV. (1994) <> Lin DY, Gong J, Gallo P, Bunn PH, Couper D. (2016) Leifer ES, Troendle JF, Kolecki A, Follmann DA. (2020) <>.


Reference manual

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0.2.0 by Eric Leifer, a year ago

Browse source code at

Authors: Eric Leifer and James Troendle

Documentation:   PDF Manual  

GPL-2 license

Depends on survival, stats, mvtnorm

Suggests knitr, rmarkdown

See at CRAN