Simulate Survival Data for Randomized Clinical Trials

A system to simulate clinical trials with time to event endpoints. Event simulation is based on Cox models allowing for covariates in addition to the treatment or group factor. Specific drop-out rates (separate from administrative censoring) can be controlled in the simulation. Other features include stratified randomization, non-proportional hazards, different accrual patterns, and event projection (timing to reach the target event) based on interim data.


Reference manual

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0.2 by Bo Zhang, 9 months ago

Browse source code at

Authors: Bo Zhang [cre, aut] , Yi Zhong [aut, ctb] , Ginny Peng [aut, ctb] , Bin Yao [aut, ctb]

Documentation:   PDF Manual  

GPL (>= 2) license

Depends on blockrand, dplyr, survival, simsurv

See at CRAN