Automated Noncompartmental Pharmacokinetic Analysis

Provides functions for automated noncompartmental pharmacokinetic (NCA) analysis using concentration-time data. The package estimates pharmacokinetic parameters including area under the concentration-time curve (AUC), area under the first moment curve (AUMC), maximum concentration (Cmax), time to maximum concentration (Tmax), terminal elimination rate constant (Kel), elimination half-life, clearance, volume of distribution, and mean residence time (MRT). It supports automatic terminal phase selection, bootstrap confidence intervals, and publication-ready concentration-time profiles. Methods are based on Gibaldi and Perrier (1982, ISBN:9780824710422).


Reference manual

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install.packages("SmartPK")

0.1.0 by N. Shreenithi, a month ago


Browse source code at https://github.com/cran/SmartPK


Authors: N. Shreenithi [aut, cre] , S. Vishnu Shankar [aut] , Balaji Kannan [aut]


Documentation:   PDF Manual  


GPL-3 license


Imports ggplot2, rlang

Suggests knitr, rmarkdown, testthat


See at CRAN