Identification of Somatic Mutation-Driven Immune Cells

A computing tool is developed to automated identify somatic mutation-driven immune cells. The operation modes including: i) inferring the relative abundance matrix of tumor-infiltrating immune cells and integrating it with a particular gene mutation status, ii) detecting differential immune cells with respect to the gene mutation status and converting the abundance matrix of significant differential immune cell into two binary matrices (one for up-regulated and one for down-regulated), iii) identifying somatic mutation-driven immune cells by comparing the gene mutation status with each immune cell in the binary matrices across all samples, and iv) visualization of immune cell abundance of samples in different mutation status..


Reference manual

It appears you don't have a PDF plugin for this browser. You can click here to download the reference manual.


0.1.3 by Junwei Han, a year ago

Browse source code at

Authors: Baotong Zheng , Junwei Han

Documentation:   PDF Manual  

GPL (>= 2) license

Imports GSVA, samr, e1071, parallel, preprocessCore, pheatmap, maftools, grDevices, survival, survminer, MASS, pracma, stats, quadprog, RColorBrewer, backports

Suggests knitr, rmarkdown

See at CRAN