Provides a classification framework to use expression patterns of pathways as features to identify similarity between biological samples. It provides a new measure for quantifying similarity between expression patterns of pathways.
SIGN fasciliotates classification and clustering of biological samples relyign on expression pattersn of biological pathways. A new measure of pathway expression pattern similarity (TSC) was introduced in the package. The package has been developed and tested for RNA-seq profiles of the cells. However, it can be used for other sequencig profiles with continuous values for each feature (gene, protein, cis-regulatory elements, etc.)
install.packages('SIGN')# Installing the development version from GitHub:# install.packages("devtools")devtools::install_github("bhklab/SIGN")