Variations of Remove Unwanted Variation-III (RUV-III) known as RUV-III-C (RUV-III Complete). RUV-III performs normalisation using negative control variables and replication. RUV-III-C extends this method to cases where the data contains missing values, by applying RUV-III to complete subsets of the data. Originally designed for SWATH-MS proteomics datasets. Poulos et al. (2020) .


Reference manual

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1.0.19 by Rohan Shah, 9 months ago

Browse source code at

Authors: Rohan Shah [aut, cre] , Sean Peters [ctb] , Qing Zhong [ctb] , Children's Medical Research Institute [cph]

Documentation:   PDF Manual  

MIT + file LICENSE license

Depends on RSpectra, progress

Suggests ruv, testthat

Linking to Rcpp, RcppEigen, RSpectra, RcppProgress

System requirements: C++11

See at CRAN