Rank Normal Transformation Omnibus Test

Genetic association tests that use the rank-based inverse normal transformation (INT). These tests are recommend for continuous traits with non-normally distributed residuals. INT-based tests robustly control the type I error in settings where standard linear regression does not. Moreover, INT-based tests dominate standard linear regression in terms of power. INT-based tests may be classified into two types: tests that directly transform the phenotype (D-INT) and tests that transform phenotypic residuals (I-INT). Our omnibus test (O-INT) adaptively combines D-INT and I-INT into a single robust and statistically powerful approach.


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install.packages("RNOmni")

0.7.1 by Zachary McCaw, 5 months ago


Browse source code at https://github.com/cran/RNOmni


Authors: Zachary McCaw [aut, cre]


Documentation:   PDF Manual  


GPL-3 license


Imports abind, foreach, plyr, Rcpp

Suggests cowplot, ggplot2, knitr, reshape2, rmarkdown

Linking to Rcpp, RcppEigen


See at CRAN