Phylogeny-Guided OTU-Specific Association Test for Microbiome Data

Implements the Phylogeny-Guided Microbiome OTU-Specific Association Test method, which boosts the testing power by adaptively borrowing information from phylogenetically close OTUs (operational taxonomic units) of the target OTU. This method is built on a kernel machine regression framework and allows for flexible modeling of complex microbiome effects, adjustments for covariates, and can accommodate both continuous and binary outcomes.


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install.packages("POSTm")

1.1 by Shannon Holloway, 18 days ago


Browse source code at https://github.com/cran/POSTm


Authors: Caizhi Huang [aut] , Jung-Ying Tzeng [aut] , Shannon Holloway [aut, cre]


Documentation:   PDF Manual  


GPL-2 license


Imports CompQuadForm, ape

Depends on methods

Suggests multtest, rmarkdown, knitr


See at CRAN