Phylogeny-Guided OTU-Specific Association Test for Microbiome Data

Implements the Phylogeny-Guided Microbiome OTU-Specific Association Test method, which boosts the testing power by adaptively borrowing information from phylogenetically close OTUs (operational taxonomic units) of the target OTU. This method is built on a kernel machine regression framework and allows for flexible modeling of complex microbiome effects, adjustments for covariates, and can accommodate both continuous and binary outcomes.


Reference manual

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1.1 by Shannon Holloway, 5 months ago

Browse source code at

Authors: Caizhi Huang [aut] , Jung-Ying Tzeng [aut] , Shannon Holloway [aut, cre]

Documentation:   PDF Manual  

GPL-2 license

Imports CompQuadForm, ape

Depends on methods

Suggests multtest, rmarkdown, knitr

See at CRAN