Bayesian Designs for Early Phase Clinical Trials

We developed a package 'Keyboard' for designing single-agent, drug-combination, or phase I/II dose-finding clinical trials. The 'Keyboard' designs are novel early phase trial designs that can be implemented simply and transparently, similar to the 3+3 design, but yield excellent performance, comparable to those of more-complicated, model-based designs (Yan F, Mandrekar SJ, Yuan Y (2017) , Li DH, Whitmore JB, Guo W, Ji Y. (2017) , Liu S, Johnson VE (2016) , Zhou Y, Lee JJ, Yuan Y (2019) , Pan H, Lin R, Yuan Y (2020)