Heritability of Gene Expression for Next-Generation Sequencing

Statistical framework to analyze heritability of gene expression based on next-generation sequencing data and simulating sequencing reads. Variance partition coefficients (VPC) are computed using linear mixed effects and generalized linear mixed effects models. Compound Poisson and negative binomial models are included. Reference: Rudra, Pratyaydipta, et al. "Model based heritability scores for high-throughput sequencing data." BMC bioinformatics 18.1 (2017): 143.


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install.packages("HeritSeq")

1.0.1 by W. Jenny Shi, 5 months ago


Report a bug at https://github.com/KechrisLab/HeritSeq/issues


Browse source code at https://github.com/cran/HeritSeq


Authors: W. Jenny Shi [aut, cre] , Pamela Russell [aut] , Pratyaydipta Rudra [aut, cre] , Brian Vestal [aut, cre] , Katerina Kechris [aut] , Laura Saba [aut]


Documentation:   PDF Manual  


GPL-2 license


Imports cplm, DESeq2, lme4, pbapply, tweedie, MASS, SummarizedExperiment

Suggests glmmADMB


See at CRAN