Heritability of Gene Expression for Next-Generation Sequencing

Statistical framework to analyze heritability of gene expression based on next-generation sequencing data and simulating sequencing reads. Variance partition coefficients (VPC) are computed using linear mixed effects and generalized linear mixed effects models. Compound Poisson and negative binomial models are included. Reference: Rudra, Pratyaydipta, et al. "Model based heritability scores for high-throughput sequencing data." BMC bioinformatics 18.1 (2017): 143.


Reference manual

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1.0.2 by W. Jenny Shi, 7 months ago

Report a bug at https://github.com/KechrisLab/HeritSeq/issues

Browse source code at https://github.com/cran/HeritSeq

Authors: W. Jenny Shi [aut, cre] , Pamela Russell [aut] , Pratyaydipta Rudra [aut, cre] , Brian Vestal [aut, cre] , Katerina Kechris [aut] , Laura Saba [aut]

Documentation:   PDF Manual  

GPL-2 license

Imports cplm, DESeq2, lme4, pbapply, tweedie, MASS, SummarizedExperiment

See at CRAN