Copula Mixed Models for Multivariate Meta-Analysis of Diagnostic Test Accuracy Studies

The bivariate copula mixed model for meta-analysis of diagnostic test accuracy studies in Nikoloulopoulos (2015) and Nikoloulopoulos (2018) . The vine copula mixed model for meta-analysis of diagnostic test accuracy studies accounting for disease prevalence in Nikoloulopoulos (2017) and also accounting for non-evaluable subjects in Nikoloulopoulos (2020) . The hybrid vine copula mixed model for meta-analysis of diagnostic test accuracy case-control and cohort studies in Nikoloulopoulos (2018) . The D-vine copula mixed model for meta-analysis and comparison of two diagnostic tests in Nikoloulopoulos (2019) . The multinomial quadrivariate D-vine copula mixed model for meta-analysis of diagnostic tests with non-evaluable subjects in Nikoloulopoulos (2020) . The one-factor copula mixed model for joint meta-analysis of multiple diagnostic tests in Nikoloulopoulos (2022) . The multinomial six-variate 1-truncated D-vine copula mixed model for meta-analysis of two diagnostic tests accounting for within and between studies dependence in Nikoloulopoulos (2024) . The 1-truncated D-vine copula mixed models for meta-analysis of diagnostic accuracy studies without a gold standard (Nikoloulopoulos, 2025) . The 1-truncated C-vine copula mixed models for network meta-analysis of multiple diagnostic tests (Nikoloulopoulos, 2026) .


Reference manual

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install.packages("CopulaREMADA")

1.8.1 by Aristidis K. Nikoloulopoulos, 13 days ago


Browse source code at https://github.com/cran/CopulaREMADA


Authors: Aristidis K. Nikoloulopoulos [aut, cre] (ORCID:


Documentation:   PDF Manual  


GPL (>= 2) license


Depends on statmod, matlab, tensor, mc2d


See at CRAN