Decomposition of Bulk Expression with Single-Cell Sequencing

Provides tools to accurately estimate cell type abundances from heterogeneous bulk expression. A reference-based method utilizes single-cell information to generate a signature matrix and transformation of bulk expression for accurate regression based estimates. A marker-based method utilizes known cell-specific marker genes to measure relative abundances across samples. For more details, see Jew and Alvarez et al (2019) .


Reference manual

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1.0.5 by Brandon Jew, 6 months ago

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Authors: Brandon Jew [aut, cre] , Marcus Alvarez [aut]

Documentation:   PDF Manual  

GPL-3 license

Imports Biobase, limSolve, methods, stats

Suggests Seurat, plyr, knitr, rmarkdown, testthat

See at CRAN