DE Analysis for Single-Cell RNA-Sequencing Data

Implements the TWO-Component Single Cell Model-Based Association Method (TWO-SIGMA) for gene-level differential expression (DE) analysis and DE-based gene set testing of single-cell RNA-sequencing datasets. See Van Buren et al. (2020) and Van Buren et al. (2021) .


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install.packages("twosigma")

1.0.2 by Eric Van Buren, a month ago


https://github.com/edvanburen/twosigma


Report a bug at https://github.com/edvanburen/twosigma/issues


Browse source code at https://github.com/cran/twosigma


Authors: Eric Van Buren [aut, cre] , Yun Li [aut] , Di Wu [aut] , Ming Hu [aut]


Documentation:   PDF Manual  


AGPL-3 license


Imports multcomp, glmmTMB, methods, pscl, pbapply, parallel, doParallel

Suggests testthat


See at CRAN