Isotonic Designs for Phase 1 Trials with Late-Onset Toxicities

Functions to design phase 1 trials using an isotonic regression based design incorporating time-to-event information. Simulation and design functions are available, which incorporate information about followup and DLTs, and apply isotonic regression to devise estimates of DLT probability.


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install.packages("titeIR")

0.1.0 by Lee McDaniel, 3 years ago


Browse source code at https://github.com/cran/titeIR


Authors: Lee McDaniel [aut, cre]


Documentation:   PDF Manual  


GPL-3 license


Imports Iso


See at CRAN