Isotonic Designs for Phase 1 Trials with Late-Onset Toxicities

Functions to design phase 1 trials using an isotonic regression based design incorporating time-to-event information. Simulation and design functions are available, which incorporate information about followup and DLTs, and apply isotonic regression to devise estimates of DLT probability.


Reference manual

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0.1.0 by Lee McDaniel, 3 years ago

Browse source code at

Authors: Lee McDaniel [aut, cre]

Documentation:   PDF Manual  

GPL-3 license

Imports Iso

See at CRAN