Simulation of Pleiotropic, Linked and Epistatic Phenotypes

The number of studies involving correlated traits and the availability of tools to handle this type of data has increased considerably in the last decade. With such a demand, we need tools for testing hypotheses related to single and multi-trait (correlated) phenotypes based on many genetic settings. Thus, we implemented various options for simulation of pleiotropy and Linkage Disequilibrium under additive, dominance and epistatic models. The simulation currently takes a marker data set as an input and then uses it for simulating multiple traits as described in Fernandes and Lipka (2020) .


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install.packages("simplePHENOTYPES")

1.2.4 by Samuel Fernandes, 6 months ago


https://github.com/samuelbfernandes/simplePHENOTYPES


Report a bug at https://github.com/samuelbfernandes/simplePHENOTYPES/issues


Browse source code at https://github.com/cran/simplePHENOTYPES


Authors: Samuel Fernandes [aut, cre] , Alexander Lipka [aut]


Documentation:   PDF Manual  


MIT + file LICENSE license


Imports data.table, mvtnorm, lqmm, stats, utils, SNPRelate, gdsfmt

Suggests knitr, rmarkdown


See at CRAN