Copy Number Profiling using Sequencing and CBS

This is a method for DNA Copy Number Profiling using Next-Generation Sequencing. It has new model and test statistics based on non-homogeneous Poisson Processes with change point models. It uses an adaptation of Circular Binary Segmentation. Also included are methods for point-wise Bayesian Confidence Interval and model selection method for the change-point model. A case and a control sample reads (normal and tumor) are required.


Reference manual

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1.2.1 by Jeremy J. Shen, 6 months ago

Browse source code at

Authors: Jeremy J. Shen , Nancy R. Zhang

Documentation:   PDF Manual  

GPL-2 license

Depends on clue

See at CRAN