Optimization Toolkit for Pharmacokinetic-Pharmacodynamic Models

A port of the Scarabee toolkit originally written as a Matlab-based application. scaRabee provides a framework for simulation and optimization of pharmacokinetic-pharmacodynamic models at the individual and population level. It is built on top of the neldermead package, which provides the direct search algorithm proposed by Nelder and Mead for model optimization.


scaRabee: Optimization toolkit for pharmacometric models

scaRabee is a port of the Scarabee toolkit originally written as a Matlab-based application. It provides a framework for simulation and optimization of pharmacometric models at the individual and population level. It is built on top of the neldermead package, which provides the direct search algorithm proposed by Nelder and Mead for model optimization.

Reference manual

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install.packages("scaRabee")

1.1-5 by Sebastien Bihorel, 8 months ago


Browse source code at https://github.com/cran/scaRabee


Authors: Sebastien Bihorel [aut, cre]


Documentation:   PDF Manual  


GPL-3 license


Imports lattice, grid, deSolve, utils, methods

Depends on neldermead, optimsimplex, optimbase

Suggests knitr, rmarkdown


See at CRAN