Regularized Continual Reassessment Method

Fit a 2-parameter continual reassessment method (CRM) model (O'Quigley and Shen (1996), ) regularized with L2 norm (Friedman et al. (2010), ) adjusted by the distance with the target dose limiting toxicity (DLT) rate.


Reference manual

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0.1.1 by Xiang Li, a year ago

Browse source code at

Authors: Xiang Li , Hong Tian , Kevin Liu , Pilar Lim

Documentation:   PDF Manual  

GPL (>= 2) license

Imports Rcpp

Linking to Rcpp, RcppEigen

See at CRAN