A Meta-Analysis Approach with Filtering for Identifying Gene-Level Gene-Environment Interactions with Genetic Association Data

Offers a gene-based meta-analysis test with filtering to detect gene-environment interactions (GxE) with association data, proposed by Wang et al. (2018) . It first conducts a meta-filtering test to filter out unpromising SNPs by combining all samples in the consortia data. It then runs a test of omnibus-filtering-based GxE meta-analysis (ofGEM) that combines the strengths of the fixed- and random-effects meta-analysis with meta-filtering. It can also analyze data from multiple ethnic groups.


Reference manual

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1.0 by Jiebiao Wang, 3 years ago


Report a bug at https://github.com/randel/ofGEM/issues

Browse source code at https://github.com/cran/ofGEM

Authors: Jiebiao Wang , Qianying Liu and Lin S. Chen

Documentation:   PDF Manual  

Task views: Meta-Analysis

GPL license

Depends on CompQuadForm, MASS, forestplot

See at CRAN