Understanding Nonlinear Mixed Effects Modeling for Population Pharmacokinetics

This shows how NONMEM(R) < http://www.iconplc.com/innovation/nonmem/> software works. NONMEM's classical estimation methods like 'First Order(FO) approximation', 'First Order Conditional Estimation(FOCE)', and 'Laplacian approximation' are explained.


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Reference manual

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install.packages("nmw")

0.1.4 by Kyun-Seop Bae, 2 years ago


https://cran.r-project.org/package=nmw


Browse source code at https://github.com/cran/nmw


Authors: Kyun-Seop Bae


Documentation:   PDF Manual  


Task views: Analysis of Pharmacokinetic Data


GPL-3 license


Depends on numDeriv


See at CRAN