Multi-Locus Random-SNP-Effect Mixed Linear Model Tools for Genome-Wide Association Study

Conduct multi-locus genome-wide association study under the framework of multi-locus random-SNP-effect mixed linear model (mrMLM). First, each marker on the genome is scanned. Bonferroni correction is replaced by a less stringent selection criterion for significant test. Then, all the markers that are potentially associated with the trait are included in a multi-locus genetic model, their effects are estimated by empirical Bayes and all the nonzero effects were further identified by likelihood ratio test for true QTL. Wen YJ, Zhang H, Ni YL, Huang B, Zhang J, Feng JY, Wang SB, Dunwell JM, Zhang YM, Wu R (2018) .


Reference manual

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4.0.2 by Yuanming Zhang, a year ago

Browse source code at

Authors: Zhang Ya-Wen , Li Pei , and Zhang Yuan-Ming

Documentation:   PDF Manual  

GPL (>= 2) license

Imports Rcpp, methods, foreach, ncvreg, coin, sampling, data.table, doParallel, sbl

Depends on lars

Linking to Rcpp, RcppEigen

Imported by mrMLM.GUI.

See at CRAN