Two Sample Mendelian Randomization using Robust Adjusted Profile Score

Mendelian randomization is a method of identifying and estimating a confounded causal effect using genetic instrumental variables. This packages implements methods for two-sample Mendelian randomization with summary statistics by using Robust Adjusted Profile Score (RAPS). References: Qingyuan Zhao, Jingshu Wang, Jack Bowden, Dylan S. Small. Statistical inference in two-sample summary-data Mendelian randomization using robust adjusted profile score. .

mr.raps is an R package for two-sample Mendelian randomization using the robust adjusted profile score. To install the package, run


The main function is mr.raps. You can find examples by running



Reference manual

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0.2 by Qingyuan Zhao, 3 years ago

Browse source code at

Authors: Qingyuan Zhao [aut, cre]

Documentation:   PDF Manual  

GPL-3 license

Imports stats, graphics, nortest

See at CRAN