Pool Literature-Based and Individual Participant Data Based Spline Estimates

Pooling estimates reported in meta-analyses (literature-based, LB) and estimates based on individual participant data (IPD) is not straight-forward as the details of the LB nonlinear function estimate are not usually reported. This package pools the nonlinear IPD dose-response estimates based on a natural cubic spline from lm or glm with the pointwise LB estimates and their estimated variances. Details will be presented in Härkänen, Tapanainen, Sares-Jäske, Männistö, Kaartinen and Paalanen (2026) "Novel pooling method for nonlinear cohort analysis and meta-analysis estimates: Predicting health outcomes based on climate-friendly diets" Epidemiology .


metasplines

Pool literature-based and individual participant data based spline estimates

Reference manual

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install.packages("metasplines")

0.1.1 by Tommi Härkänen, 9 months ago


Browse source code at https://github.com/cran/metasplines


Authors: Tommi Härkänen [aut, cre]


Documentation:   PDF Manual  


GPL (>= 3) license


Imports rlang, dplyr, tidyr, tibble, stringr, meta, optimization

Suggests knitr, rmarkdown, splines2


See at CRAN