Tools for subgroup analyses with multiple trial data using aggregate statistics

This package provides functions to estimate an IPD linear mixed effects model for a continuous outcome and any categorical covariate from study summary statistics. There are also functions for estimating the power of a treatment-covariate interaction test in an individual patient data meta-analysis from aggregate data.


*** Version 2.3 ***

Methods for estimating an IPD linear mixed effects model from study-level data have been added. See the manual page for ipdlme.

*** Version 2.4 ***

Option added to ipdlme to allow heterogeneous residual variance with option equal.resid.var.

Reference manual

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2.4 by S. Kovalchik, 8 years ago

Browse source code at

Authors: S. Kovalchik

Documentation:   PDF Manual  

Task views: Meta-Analysis, Survival Analysis

GPL-2 license

Depends on nlme, methods

See at CRAN