Adaptive Enrichment Designs with Sample Size Re-Estimation

Software of 'esDesign' is developed to implement the adaptive enrichment designs with sample size re-estimation presented in Lin et al. (2021) . In details, three-proposed trial designs are provided, including the AED1-SSR (or ES1-SSR), AED2-SSR (or ES2-SSR) and AED3-SSR (or ES3-SSR). In addition, this package also contains several widely used adaptive designs, such as the Marker Sequential Test (MaST) design proposed Freidlin et al. (2014) , the adaptive enrichment designs without early stopping (AED or ES), the sample size re-estimation procedure (SSR) based on the conditional power proposed by Proschan and Hunsberger (1995), and some useful functions. In details, we can calculate the futility and/or efficacy stopping boundaries, the sample size required, calibrate the value of the threshold of the difference between subgroup-specific test statistics, conduct the simulation studies in AED, SSR, AED1-SSR, AED2-SSR and AED3-SSR.


esDesign 1.0.1

  • Added a file to track changes to the package.

Reference manual

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1.0.3 by Zhao Yang, 5 months ago

Browse source code at

Authors: Zhao Yang , Ruitao Lin , Guosheng Yin and Ying Yuan

Documentation:   PDF Manual  

GPL-2 license

Imports stats

Suggests knitr, rmarkdown

See at CRAN