Phase I/II Adaptive Dose-Finding Design for Combination Studies

Phase I/II adaptive dose-finding design for combination studies. Several methods are proposed depending on the type of combinations: (1) the combination of two cytotoxic agents, and (2) combination of a molecularly targeted agent with a cytotoxic agent.


Reference manual

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2.4-2 by Jacques-Henri Jourdan, 2 months ago

Browse source code at

Authors: Marie-Karelle Riviere and Jacques-Henri Jourdan

Documentation:   PDF Manual  

Task views: Design of Experiments (DoE) & Analysis of Experimental Data

GPL-3 license

Linking to RcppArmadillo, BH, RcppProgress, Rcpp

See at CRAN