Phase I/II Adaptive Dose-Finding Design for Combination Studies

Phase I/II adaptive dose-finding design for combination studies where toxicity rates are supposed to increase with both agents.


Reference manual

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3.0-0 by Jacques-Henri Jourdan, a year ago

Browse source code at

Authors: Marie-Karelle Riviere and Jacques-Henri Jourdan

Documentation:   PDF Manual  

Task views: Design of Experiments (DoE) & Analysis of Experimental Data

GPL-3 license

Linking to BH, Rcpp, RcppProgress

See at CRAN