Phase I/II Adaptive Dose-Finding Design for Combination Studies

Phase I/II adaptive dose-finding design for combination studies. Several methods are proposed depending on the type of combinations: (1) the combination of two cytotoxic agents, and (2) combination of a molecularly targeted agent with a cytotoxic agent.


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install.packages("dfcomb")

2.4-2 by Jacques-Henri Jourdan, 8 days ago


Browse source code at https://github.com/cran/dfcomb


Authors: Marie-Karelle Riviere and Jacques-Henri Jourdan


Documentation:   PDF Manual  


Task views: Design of Experiments (DoE) & Analysis of Experimental Data


GPL-3 license


Linking to RcppArmadillo, BH, RcppProgress, Rcpp


See at CRAN