Interim Monitoring Using Adaptively Weighted Log-Rank Test in Clinical Trials

For any spending function specified by the user, this package provides corresponding boundaries for interim testing using the adaptively weighted log-rank test developed by Yang and Prentice (2010 ). The package uses a re-sampling method to obtain stopping boundaries at the interim looks.The output consists of stopping boundaries and observed values of the test statistics at the interim looks, along with nominal p-values defined as the probability of the test exceeding the specific observed test statistic value or critical value, regardless of the test behavior at other looks. The asymptotic validity of the stopping boundaries is established in Yang (2018 ).


Provide monitoring boundaries for interim testing using the adaptively weighted log-rank test developed by Yang and Prentice (2010). The package use a re-sampling method to obtain stopping boundaries in sequential designs. The asymptotic distribution of the test statistics of the adaptively weighted log-rank test at the interim looks is examined in Yang (2017, pre-print).

Installation

install.packages("YPInterimTesting")

Example

library(YPInterimTesting)
data(virtual_data)
spenfun <- c(1.3E-5, 4.4E-4, 0.003, 0.008)

result <- ypinterim(time=virtual$time, event=virtual$event, group=virtual$group, spenfun=spenfun)
result

The data "virtual" is a virtual data set created to show how to utilize the package. Any inference cannot be drawn from this data set. The object result can be formatted to a table using the function summary.

summary(result)

Reference

Yang, S. and Prentice, R. (2010), Improved Weights. Biometrics, 66: 30–38.

Yang, S . Interim monitoring using the adaptively weighted log-rank test in clinical trials for survival outcomes. 2017. Pre-print.

News

YPInterimTesting 0.1.0

  • The initial version

Reference manual

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install.packages("YPInterimTesting")

1.0.0 by Daewoo Pak, 2 months ago


Browse source code at https://github.com/cran/YPInterimTesting


Authors: Daewoo Pak and Song Yang


Documentation:   PDF Manual  


GPL (>= 3) license


Imports Rcpp, MASS

Linking to Rcpp


See at CRAN